Biomarker: GST-pi

Histology type: endometrial carcinoma

Country: Japan

Region: Hirosaki

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 22

Subgroup 2 name: negative

Subgroup 2 number: 39

Conclusion: These results suggest that the expressions of GST-pi and c-Jun may reflect the metastatic potential of endometrial carcinomas and that their expressions of endometrial carcinoma may be useful as a prognostic indicator for predictive testing.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : positive expression

Expression elevation: Stained sections were compared with controls, and carcinomas in which 30% or more of the component cells were stained for GST-p or oncogene products were evaluated as positive, whereas tissues consisting of less than 30% stained cells were counted as negative

Funtion Uniprot: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration

UniProt ID: P09211

UniProt Link: https://www.uniprot.org/uniprotkb/P09211/entry

Biological function from UniProt: #Lipid metabolism

Molecular function from UniProt:

Subcellular UniProt: #Cytoplasm #Mitochondrion #Nucleus

Alternative name from UniProt:

Catalytic activity: glutathione + RX = a halide anion + an S-substituted glutathione + H+,This reaction proceeds in the forward direction.glutathione + prostaglandin J2 = prostaglandin J2-S-(R)-glutathione,This reaction proceeds in the forward direction.glutathione + prostaglandin J2 = prostaglandin J2-S-(S)-glutathione,This reaction proceeds in the forward direction.glutathione + prostaglandin A2 = prostaglandin A2-S-(S)-glutathione,This reaction proceeds in the forward direction.11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate,This reaction proceeds in the forward direction.

Recommended name: Glutathione S-transferase P

Gene name from HGNC: GSTP1 (FAEES3, GST3, GSTP)

HPA class: Cancer-related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins

AlphaFold DB: P09211

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P09211

HPA link: https://www.proteinatlas.org/ENSG00000084207-GSTP1

Tissue specificity RNA from HPA: Tissue enhanced (esophagus)

Tissue expression from HPA: Cytoplasmic expression in most tissues.

Single cell type specificity Cell type enhanced (Squamous epithelial cells)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Mitochondria, Cytosol (Single cell variability)

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000084207-GSTP1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000084207-GSTP1/pathology/endometrial+cancer

OMIM: 134660

OMIM link2: https://www.omim.org/entry/134660

HGNC ID: HGNC:4638

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4638