Biomarker: PP14

Histology type: endometrioid endometrial carcinoma

Country: UK

Region: Sheffield

Followed up time :

Conclusion: Elevated PP14 concentrations are also associated with the presence of endometrial adenocarcinoma and may have a potential to be used as a marker for this disease.

Sample type : plasma

Sample method: radioimmunoassay

Expression pattern : elevated concentrations

Funtion Uniprot: Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).

UniProt ID: P09466

UniProt Link: https://www.uniprot.org/uniprotkb/P09466/entry

Molecular function from UniProt:

Tissue specificity from UniProt: This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877). Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) (PubMed:3194393). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) (PubMed:12672671). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) (PubMed:9239694). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling (PubMed:17192260).

Subcellular UniProt: #Secreted

Alternative name from UniProt:

Recommended name: Glycodelin

Gene name from HGNC: PAEP (GD, GdA, GdF, GdS, MGC138509, MGC142288, PAEG, PEP, PP14)

AlphaFold DB: P09466

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P09466

HPA link: https://www.proteinatlas.org/ENSG00000122133-PAEP

Tissue specificity RNA from HPA: Tissue enhanced (cervix, endometrium)

Tissue expression from HPA: Selective cytoplasmic expression in decidual cells and a subset of uterine glands.

Single cell type specificity Cell type enriched (Glandular and luminal cells)

Immune cell specificity: Group enriched (basophil, neutrophil)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), liver cancer (unfavorable) and stomach cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000122133-PAEP/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000122133-PAEP/pathology/endometrial+cancer

OMIM: 173310

OMIM link2: https://www.omim.org/entry/173310

HGNC ID: HGNC:8573

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8573