Basic information
Biomarker: syndecan-1
Histology type: endometrial carcinoma
Cohort characteristics
Country: Poland
Region: Lublin
Followed up time :
Subgroup 1 name : positive
Subgroup 1 number: 12
Subgroup 2 name: negative
Subgroup 2 number: 18
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 30 | EC | 30 |
Sample information
Conclusion: The detection of syndecan-1 in endometrial cancer of different clinical and histological stages could be of prognostic value in clinical diagnosis.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : expression
Disease information
Related information
Funtion Uniprot: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
UniProt ID: P18827
UniProt Link: https://www.uniprot.org/uniprotkb/P18827/entry
Molecular function from UniProt:
Subcellular UniProt: #Membrane #Secreted
Recommended name: Syndecan-1
Gene name from HGNC: SDC1 (CD138, SDC, SYND1, syndecan)
CD antigen name: CD138
HPA class: Cancer-related genes CD markers Metabolic proteins Plasma proteins Transporters
AlphaFold DB: P18827
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P18827
HPA link: https://www.proteinatlas.org/ENSG00000115884-SDC1
Tissue specificity RNA from HPA: Tissue enhanced (esophagus, liver, skin)
Tissue expression from HPA: Membranous expression in plasma cells, also expressed in epithelial cells, for example in placenta.
Single cell type specificity Cell type enhanced (Hepatocytes, Urothelial cells, Cholangiocytes, Syncytiotrophoblasts, Squamous epithelial cells)
Immune cell specificity: Not detected in immune cells
Subcellular summary HPA Located in Focal adhesion sites
Cancer prognostic summary HPA Prognostic marker in breast cancer (unfavorable) and glioma (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000115884-SDC1/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000115884-SDC1/pathology/endometrial+cancer
OMIM: 186355
OMIM link2: https://www.omim.org/entry/186355
HGNC ID: HGNC:10658
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10658
