Biomarker: cathepsin D (Cat D)

Histology type: endometrioid endometrial carcinoma

Country: Spain

Region: Canary Islands

Followed up time :

Subgroup 1 name : low Cat D level

Subgroup 1 number: 60

Subgroup 2 name: high Cat D level

Subgroup 2 number: 96

Conclusion: We conclude that Cat D is an independent prognostic factor in endometrial adenocarcinoma, its low levels being associated with a worse clinical outcome.

Sample type : tissue

Sample method: ELISAs

Expression pattern : Low levels(cuoff 40 pmol mg–1 protein)

Statictics: cutoff<65;cutoff>65

Cohort age: 156

Subgroup 1 age: 75

Funtion Uniprot: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease

UniProt ID: P07339

UniProt Link: https://www.uniprot.org/uniprotkb/P07339/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).

Subcellular UniProt: #Lysosome #Secreted

Cleaved: Cleaved into 2 chains Cathepsin D light chain Cathepsin D heavy chain

Catalytic activity: Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.

Recommended name: Cathepsin D

Gene name from HGNC: CTSD (CLN10, CPSD)

HPA class: Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets

AlphaFold DB: P07339

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P07339

HPA link: https://www.proteinatlas.org/ENSG00000117984-CTSD

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic expression with a granular in all tissues.

Single cell type specificity Cell type enhanced (Hofbauer cells, Proximal enterocytes, Macrophages, Distal enterocytes)

Immune cell specificity: Low immune cell specificity

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable) and colorectal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000117984-CTSD/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000117984-CTSD/pathology/endometrial+cancer

Phenotype ID: 610127

Disease: Ceroid lipofuscinosis, neuronal, 10 (CLN10)

Note1: The disease is caused by variants affecting the gene represented in this entry;

OMIM: 116840

OMIM link1: https://www.omim.org/entry/610127

OMIM link2: https://www.omim.org/entry/116840

HGNC ID: HGNC:2529

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2529