Biomarker: Id1

Histology type: endometrial carcinoma

Country: Japan

Region: Oita

Followed up time :

Conclusion: Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : overexpression

Expression elevation: The intensities, percentages, and patterns of immunohistochemical staining for each sample slide were recorded separately. The percentage of immunoreactive cells was calculated by counting at least 1,000 tumor cells at high magnification ×400†.

Statictics: Mean (SD)

Cohort age: 40 ±6

Funtion Uniprot: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity)

UniProt ID: P41134

UniProt Link: https://www.uniprot.org/uniprotkb/P41134/entry

Biological function from UniProt: #Biological rhythms #Transcription #Transcription regulation

Molecular function from UniProt:

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Recommended name: DNA-binding protein inhibitor ID-1

Gene name from HGNC: ID1 (bHLHb24, dJ857M17.1.2)

HPA class: Cancer-related genes Plasma proteins Transcription factors

AlphaFold DB: P41134

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P41134

Developmental stage: Expression correlates with proliferation in some types of cells.

HPA link: https://www.proteinatlas.org/ENSG00000125968-ID1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic and nuclear expression in all tissues.

Single cell type specificity Cell type enhanced (Hepatic stellate cells, Adipocytes, Basal respiratory cells)

Immune cell specificity: Immune cell enriched (neutrophil)

Subcellular summary HPA Located in Nucleoplasm (Single cell variability, CCD Protein)

Cancer prognostic summary HPA Prognostic marker in lung cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000125968-ID1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000125968-ID1/pathology/endometrial+cancer

OMIM: 600349

OMIM link2: https://www.omim.org/entry/600349

HGNC ID: HGNC:5360

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5360