Biomarker: endostatin

Histology type: endometrial carcinoma

Country: Egypt

Region: Cairo

Study type: Comparative Study

Followed up time :

Conclusion: Serum VEGF and endostatin levels decreased significantly after treatment, followed by marked elevations at clinical relapse.

Sample type : serum

Sample method: ELISA

Expression pattern : serum endostatin level

Funtion Uniprot: Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Non-collagenous domain 1 May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. Endostatin Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123).

UniProt ID: P39060

UniProt Link: https://www.uniprot.org/uniprotkb/P39060/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Present in multiple organs with highest levels in liver, lung and kidney.

Subcellular UniProt: #Basement membrane #Extracellular matrix #Secreted

Alternative name from UniProt:

Caution: Non-collagenous domain 1 seems to be the predominant tissue form from which endostatin is cleaved. However, the proteolytic cleavage site to generate non-collagenous domain 1 is not known. Soluble recombinant non-collagenous domain 1 amenable to biochemical studies has been used instead.

Miscellaneous: Endostatin Available under the name Endostar (Jiangsu Simcere Pharmaceutical) for the treatment of non-small-cell lung cancer.

Recommended name: Collagen alpha-1(XVIII) chain

Gene name from HGNC: COL18A1 (KNO, KNO1, KS)

HPA class: Cancer-related genes Disease related genes Human disease related genes Plasma proteins

AlphaFold DB: P39060

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P39060

HPA link: https://www.proteinatlas.org/ENSG00000182871-COL18A1

Tissue specificity RNA from HPA: Tissue enhanced (liver)

Tissue expression from HPA: Positivity in extracellular matrix combined with cytoplasmic expression in most tissues.

Single cell type specificity Cell type enhanced (Hepatocytes, Smooth muscle cells, Sertoli cells)

Immune cell specificity: Immune cell enhanced (neutrophil)

Subcellular summary HPA Located in Golgi apparatus

Cancer prognostic summary HPA Prognostic marker in liver cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000182871-COL18A1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000182871-COL18A1/pathology/endometrial+cancer

Phenotype ID: 267750;618880;

Disease: Knobloch syndrome 1 (KNO1);Glaucoma, primary closed-angle (GLCC);

Note1: The disease is caused by variants affecting the gene represented in this entry;The disease may be caused by variants affecting the gene represented in this entry;

OMIM: 120328

OMIM link1: https://www.omim.org/entry/267750;https://www.omim.org/entry/618880;

OMIM link2: https://www.omim.org/entry/120328

HGNC ID: HGNC:2195

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2195