Biomarker: HE4

Histology type: endometrial carcinoma

Study type: Meta-Analysis

Followed up time :

Conclusion: High HE4 concentrations in patients with endometrial cancer are found to be associated with shorter survival

Sample type : serum

Sample method: Meta-Analysis

Funtion Uniprot: Broad range protease inhibitor.

UniProt ID: Q14508

UniProt Link: https://www.uniprot.org/uniprotkb/Q14508/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.

Subcellular UniProt: #Secreted

Alternative name from UniProt:

Recommended name: WAP four-disulfide core domain protein 2

Gene name from HGNC: WFDC2 (dJ461P17.6, EDDM4, HE4, WAP5)

HPA class: Cancer-related genes

AlphaFold DB: Q14508

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q14508

HPA link: https://www.proteinatlas.org/ENSG00000101443-WFDC2

Tissue specificity RNA from HPA: Tissue enhanced (cervix, salivary gland)

Tissue expression from HPA: Cytoplasmic expression in selected tissues.

Single cell type specificity Cell type enhanced (Club cells, Glandular and luminal cells, Basal respiratory cells, Urothelial cells, Endometrial ciliated cells, Respiratory ciliated cells, Collecting duct cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Secreted

Cancer prognostic summary HPA Prognostic marker in glioma (unfavorable) and renal cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000101443-WFDC2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000101443-WFDC2//pathology/endometrial+cancer

OMIM: 617548

OMIM link2: https://www.omim.org/entry/617548

HGNC ID: HGNC:15939

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15939