Biomarker: UPAR

Histology type: endometrial carcinoma

Stage: high risk

Country: USA

Region: CA

Study type: retrospective study

Followed up time :

Subgroup 1 name : High expression

Subgroup 1 number: 35

Subgroup 2 name: Low expression

Subgroup 2 number: 23

Conclusion: Our data suggest that UPAR is a useful prognostic marker for biologically aggressive forms of endometrial cancer.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high expression

Expression elevation: The evaluations were recorded as percentages of positive staining which were denoted as 0 (no staining), 1+ (weak staining but detectable above control), 2+ (distinct), and 3+ (intense staining). We categorized staining intensities of 1+ or 2+ into the low group and 3+ into the high group to help focus on the most abundant UPAR protein staining.

Funtion Uniprot: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

UniProt ID: Q03405

UniProt Link: https://www.uniprot.org/uniprotkb/Q03405/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Subcellular UniProt: #Cell junction #Cell membrane #Cell projection #Membrane #Secreted

Alternative name from UniProt:

Recommended name: Urokinase plasminogen activator surface receptor

Gene name from HGNC: PLAUR (CD87, UPAR, URKR)

CD antigen name: CD87

HPA class: Cancer-related genes CD markers FDA approved drug targets

AlphaFold DB: Q03405

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q03405

HPA link: https://www.proteinatlas.org/ENSG00000011422-PLAUR

Tissue specificity RNA from HPA: Tissue enriched (bone marrow)

Tissue expression from HPA: High cytoplasmic expression in respiratory epithelia and in a subset of cells of bone marrow.

Single cell type specificity Cell type enhanced (Urothelial cells, Langerhans cells, Macrophages, Basal prostatic cells)

Immune cell specificity: Immune cell enhanced (neutrophil)

Subcellular summary HPA Located in Plasma membrane

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable) and lung cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000011422-PLAUR/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000011422-PLAUR/pathology/endometrial+cancer

Expression figure legend: UPAR protein expression is abundant and specific in adenocarcinoma of the endometrium.$ he degree of UPAR protein expression correlates with histologic grade in specimens from patients with adenocarcinoma of the endometrium

Expression figure link: https://pubmed.ncbi.nlm.nih.gov/12130664/#&gid=article-figures&pid=fig-1-uid-0 $ https://www.pnas.org/doi/10.1073/pnas.152127499?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed#f2

OMIM: 173391

OMIM link2: https://www.omim.org/entry/173391

HGNC ID: HGNC:9053

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9053