Biomarker: cyclin A

Histology type: endometrial carcinoma

Country: Japan

Region: Matsumoto

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 25

Subgroup 2 name: negative

Subgroup 2 number: 57

Conclusion: These findings suggest that various cell-cycle regulators are involved in activated cell growth of endometrial carcinoma, and that positive staining for cyclin A could be a useful marker for unfavorable patient prognosis.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : positive expression

Expression elevation: The endometrial carcinoma contained more than 1% positive cells for the cell-cycle–related molecules the case was regarded as “positive,” because the PI of these molecules in the normal proliferative endometrial glandular cells was <1%

Statictics: Median;Range

Cohort age: 61;27-78

Funtion Uniprot: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.

UniProt ID: P78396

UniProt Link: https://www.uniprot.org/uniprotkb/P78396/entry

Biological function from UniProt: #Cell cycle #Cell division #Mitosis

Molecular function from UniProt:

Tissue specificity from UniProt: Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: Cyclin-A1

Gene name from HGNC: CCNA1 (CT146)

HPA class: Cancer-related genes

AlphaFold DB: P78396

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P78396

HPA link: https://www.proteinatlas.org/ENSG00000133101-CCNA1

Tissue specificity RNA from HPA: Tissue enhanced (parathyroid gland, testis)

Tissue expression from HPA: Expression in mainly in testis.

Single cell type specificity Group enriched (Spermatocytes, Early spermatids, Endometrial ciliated cells, Late spermatids)

Immune cell specificity: Immune cell enriched (basophil)

Subcellular summary HPA Located in Nucleoplasm, Nuclear bodies

Cancer prognostic summary HPA Prognostic marker in head and neck cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000133101-CCNA1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000133101-CCNA1/pathology/endometrial+cancer

OMIM: 150210

OMIM link2: https://www.omim.org/entry/150210

HGNC ID: HGNC:1577

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1577