Biomarker: ERRα(+)

Histology type: endometrioid endometrial carcinoma

Country: China

Region: Fuzhou

Followed up time :

Conclusion: A dynamic imbalance between PPARγ and ERRα leads to endometrial carcinogenesis and predicts the EC prognosis.

Sample type : tissue

Sample method: immunohistochemistry/qRT-PCR

Expression pattern : PPARγ(-)/ERRα (+)ratio≤1.86 

Expression elevation: A semiquantitative grading system incorporating staining intensity (score, 0–3) and tumor area with positive staining (0, 0%; 1, 1%-25%; 2, 26%–50%; 3, 51%-75%; and 4, 76%-100% of tumor cells) was applied. The staining index (SI) was calculated as the product of staining intensity and area and ranged from 0 to 12, as described in several publications. Immunohistochemical activity was stratified by the SI (-, 1-2; +, 3-4; ++, 5-8; and +++, 9-12). Immunological activities were classified as positive (+, ++, +++) and negative (-).

Statictics: Median

Cohort age: 55

Funtion Uniprot: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.

UniProt ID: P11474

UniProt Link: https://www.uniprot.org/uniprotkb/P11474/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Induced by PGC1alpha in a number of specific cell types including heart, kidney and muscle

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Recommended name: Steroid hormone receptor ERR1

Gene name from HGNC: ESRRA (ERR1, ERRa, ERRalpha, ESRL1, NR3B1)

HPA class: Nuclear receptors Transcription factors

AlphaFold DB: P11474

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P11474

HPA link: https://www.proteinatlas.org/ENSG00000173153-ESRRA

Tissue specificity RNA from HPA: Tissue enhanced (skeletal muscle)

Tissue expression from HPA: General cytoplasmic expression.

Single cell type specificity Cell type enhanced (Hepatocytes, Proximal enterocytes, Distal enterocytes)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Nucleoli fibrillar center, Microtubules, Cytokinetic bridge (Single cell variability, CCD Protein)

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000173153-ESRRA/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000173153-ESRRA/pathology/endometrial+cancer

Expression figure legend: PPARγ was negatively correlated with ERRα in EC tissue.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746384/figure/f1/

Survival figure legend: Diagnostic and prognostic value of the PPARγ/ERRα ratio for EC.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746384/figure/f5/

OMIM: 601998

OMIM link2: https://www.omim.org/entry/601998

HGNC ID: HGNC:3471

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3471