Basic information
Biomarker: Elf-1
Histology type: endometrial carcinoma
Cohort characteristics
Country: Japan
Region: Oita
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 51 | EC | 31 | normal endometria | 20 |
Sample information
Conclusion: Our results demonstrate that Elf-1 expression in endometrial carcinoma correlates with the malignant potential of this tumor.
Sample type : tissue
Sample method: fluorescent immunohistochemistry
Expression pattern : overexpression
Expression elevation: The percentage of nuclear-stained cells was calculated by counting at least 1000 tumor cells at high magnification (400).
Disease information
Statictics: Mean (SD)
Cohort age: 61.2 ± 10.65
Related information
Funtion Uniprot: Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer
UniProt ID: P32519
UniProt Link: https://www.uniprot.org/uniprotkb/P32519/entry
Biological function from UniProt: #Transcription #Transcription regulation
Molecular function from UniProt:
Tissue specificity from UniProt: In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.
Subcellular UniProt: #Nucleus
Alternative name from UniProt:
Recommended name: ETS-related transcription factor Elf-1
Gene name from HGNC: ELF1
HPA class: Transcription factors
AlphaFold DB: P32519
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P32519
HPA link: https://www.proteinatlas.org/ENSG00000120690-ELF1
Tissue specificity RNA from HPA: Tissue enhanced (bone marrow)
Tissue expression from HPA: General nuclear expression.
Single cell type specificity Cell type enhanced (T-cells)
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA Located in Nucleoplasm
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000120690-ELF1/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000120690-ELF1/pathology/endometrial+cancer
OMIM: 189973
OMIM link2: https://www.omim.org/entry/189973
HGNC ID: HGNC:3222
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3222
