Biomarker: endoglin (CD105)

Histology type: endometrial carcinoma

Country: Germany

Region: Munich

Study type: retrospective study

Followed up time :

Subgroup 1 name : EC

Subgroup 1 number: 55

Subgroup 2 name: CHA;SH

Subgroup 2 number: 20

Conclusion: Our study showed that endoglin, by staining the proliferating MV in EC, is a more specific and sensitive marker for tumor angiogenesis than is the commonly used pan-endothelial marker, CD31. Endoglin staining also had prognostic significance, with positive correlation with angiolymphatic invasion, lymph node metastases, and tumor stage.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : positive expression

Statictics: Mean (SD);Range

Subgroup 1 age: 61.2 ± 10.65;40-88

Subgroup 2 age: 50.1 ± 6.9; 48 ± 6.2;40-66;40-68

Funtion Uniprot: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529)

UniProt ID: P17813

UniProt Link: https://www.uniprot.org/uniprotkb/P17813/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Detected on umbilical veil endothelial cells (PubMed:10625079). Detected in placenta (at protein level) (PubMed:1692830). Detected on endothelial cells (PubMed:1692830).

Subcellular UniProt: #Cell membrane #Membrane

Recommended name: Endoglin

Gene name from HGNC: ENG (CD105, END, HHT1, ORW, ORW1)

CD antigen name: CD105

AlphaFold DB: P17813

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P17813

HPA link: https://www.proteinatlas.org/ENSG00000106991-ENG

Tissue specificity RNA from HPA: Tissue enhanced (heart muscle)

Tissue expression from HPA: Selective expression in endothelial cells and placental trophoblasts.

Subcellular summary HPA Located in Nuclear bodies, Plasma membrane (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in liver cancer (favorable), renal cancer (unfavorable) and head and neck cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000106991-ENG/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000106991-ENG/pathology/endometrial+cancer

Phenotype ID: 187300

Disease: Telangiectasia, hereditary hemorrhagic, 1 (HHT1)

Note1: The disease is caused by variants affecting the gene represented in this entry

Note2: HHT TELANGIECTASIA, HEREDITARY HEMORRHAGIC, OF RENDU, OSLER, AND WEBER OSLER-RENDU-WEBER DISEASE ORW DISEASE

OMIM: 131195;187300;

OMIM link1: https://www.omim.org/entry/187300

OMIM link2: https://www.omim.org/entry/131195;

Phenotype: TELANGIECTASIA, HEREDITARY HEMORRHAGIC, TYPE 1; HHT1

HGNC ID: HGNC:3349

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3349