Biomarker: PPARγ(-)

Histology type: endometrioid endometrial carcinoma

Country: China

Region: Fuzhou

Followed up time :

Conclusion: A dynamic imbalance between PPARγ and ERRα leads to endometrial carcinogenesis and predicts the EC prognosis.

Sample type : tissue

Sample method: immunohistochemistry/qRT-PCR

Expression pattern : PPARγ(-)/ERRα (+)ratio≤1.86 

Expression elevation: A semiquantitative grading system incorporating staining intensity (score, 0–3) and tumor area with positive staining (0, 0%; 1, 1%-25%; 2, 26%–50%; 3, 51%-75%; and 4, 76%-100% of tumor cells) was applied. The staining index (SI) was calculated as the product of staining intensity and area and ranged from 0 to 12, as described in several publications. Immunohistochemical activity was stratified by the SI (-, 1-2; +, 3-4; ++, 5-8; and +++, 9-12). Immunological activities were classified as positive (+, ++, +++) and negative (-).

Statictics: Median

Cohort age: 55

Funtion Uniprot: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).(Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.

UniProt ID: P37231

UniProt Link: https://www.uniprot.org/uniprotkb/P37231/entry

Biological function from UniProt: Biological rhythms, Transcription, Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Activity regulation: PDPK1 activates its transcriptional activity independently of its kinase activity.

Recommended name: Peroxisome proliferator-activated receptor gamma

Gene name from HGNC: PPARG (NR1C3, PPARG1, PPARG2, PPARgamma)

HPA class: Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Nuclear receptors Plasma proteins Transcription factors

AlphaFold DB: P37231

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P37231

Induction: (Microbial infection) Expression increases when incubated with M.tuberculosis or its lipoprotein LpqH; induction is TLR2-dependent (at protein level).

HPA link: https://www.proteinatlas.org/ENSG00000132170-PPARG

Tissue specificity RNA from HPA: Tissue enhanced (adipose tissue)

Tissue expression from HPA: Cytoplasmic and nuclear expression in several tissues.

Single cell type specificity Cell type enhanced (Adipocytes, Urothelial cells, Granulosa cells, Extravillous trophoblasts)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm, Vesicles

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable), liver cancer (unfavorable) and urothelial cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000132170-PPARG/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000132170-PPARG/pathology/endometrial+cancer;

Expression figure legend: PPARγ was negatively correlated with ERRα in EC tissue.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746384/figure/f1/

Survival figure legend: Diagnostic and prognostic value of the PPARγ/ERRα ratio for EC.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746384/figure/f5/

Phenotype ID: 601665

Disease: Obesity (OBESITY) ;Lipodystrophy, familial partial, 3 (FPLD3);Glioma 1 (GLM1);

Note1: Disease susceptibility may be associated with variants affecting the gene represented in this entry ;The disease is caused by variants affecting the gene represented in this entry; Disease susceptibility may be associated with variants affecting the gene represented in this entry. Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.;

OMIM: 601487

OMIM link1: https://www.omim.org/entry/601665;https://www.omim.org/entry/604367;https://www.omim.org/entry/604367;

OMIM link2: https://www.omim.org/entry/601487

HGNC ID: HGNC:9236

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9236