Biomarker: oxytocin receptor

Histology type: endometrial stromal tumor

Country: Germany

Region: Berlin

Followed up time :

Subgroup 1 name : Positive in LMS

Subgroup 1 number: 8

Subgroup 2 name: negative in LMS

Subgroup 2 number: 8

Conclusion: Our study indicates that the evaluation of OTR expression is useful in the distinction of uterine smooth muscle tumors from ESSs, and that the OTR is expressed in normal and neoplastic uterine smooth muscle cells.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : evaluation

Expression elevation: We determined the percentage of positive tumor cells and the intensity of the staining (strong, moderate, weak).

Funtion Uniprot: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

UniProt ID: P30559

UniProt Link: https://www.uniprot.org/uniprotkb/P30559/entry

Molecular function from UniProt:

Subcellular UniProt: #Cell membrane #Membrane

Recommended name: Oxytocin receptor

Gene name from HGNC: OXTR

HPA class: FDA approved drug targets G-protein coupled receptors Transporters

AlphaFold DB: P30559

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P30559

HPA link: https://www.proteinatlas.org/ENSG00000180914-OXTR

Tissue specificity RNA from HPA: Group enriched (brain, breast)

Single cell type specificity Cell type enhanced (Breast myoepithelial cells, Respiratory ciliated cells, Excitatory neurons, Oligodendrocyte precursor cells)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000180914-OXTR/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000180914-OXTR/pathology/endometrial+cancer

OMIM: 167055

OMIM link2: https://www.omim.org/entry/167055

HGNC ID: HGNC:8529

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8529