Biomarker: LGALS3BP

Histology type: endometrial carcinoma

Country: China

Region: Shanghai

Followed up time :

Conclusion: High LGALS3BP expression was observed in human EC tissue, which indicated a poor prognosis.

Sample type : tissue

Sample method: immunohistochemistry,western blot and qRT-PCR

Expression pattern : higher expression

Expression elevation: Each sample was scored according to the intensity of staining (0 = no staining; 1 = weak staining; 2 = moderate staining; 3 = strong staining) and the proportion of cells (0 = 0%; 1 = 1–25%; 2 = 25–50%; 3 = 50–75%; 4 =75–100%).

Funtion description: Highly contained exosomal LGALS3BP contributed to EC cell proliferation and migration and HUVEC functions via the activation of the PI3K/AKT/VEGFA signalling pathway both in vitro and in vivo. Immunohistochemical analysis of human EC tissues revealed that LGALS3BP expression was correlated with VEGFA expression and blood vessel density.

Funtion Uniprot: Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.

UniProt ID: Q08380

UniProt Link: https://www.uniprot.org/uniprotkb/Q08380/entry

Biological function from UniProt: Cell adhesion

Molecular function from UniProt:

Tissue specificity from UniProt: Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.

Subcellular UniProt: #Extracellular matrix #Secreted

Alternative name from UniProt:

Recommended name: Galectin-3-binding protein

Gene name from HGNC: LGALS3BP (90K, BTBD17B, CyCAP, gp90, M2BP, MAC-2-BP, TANGO10B)

HPA class: Cancer-related genes Plasma proteins

AlphaFold DB: Q08380

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q08380

HPA link: https://www.proteinatlas.org/ENSG00000108679-LGALS3BP

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Secreted positivity and cytoplasmic expression in a majority of tissues.

Single cell type specificity Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Secreted to blood

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000108679-LGALS3BP/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000108679-LGALS3BP/pathology/endometrial+cancer;

OMIM: 600626

OMIM link2: https://www.omim.org/entry/600626

HGNC ID: HGNC:6564

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6564