Biomarker: placental leucine aminopeptidase

Histology type: endometrioid endometrial carcinoma

Country: Japan

Region: Nagoya

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 69

Subgroup 2 name: negative

Subgroup 2 number: 30

Conclusion: This study suggests P-LAP as an independent prognosticator of clinical outcome in patients with endometrial carcinoma. Therefore, assessment of the P-LAP status provides clinically useful prognostic information in patients with endometrial carcinoma.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : strongly positive

Expression elevation: Immunostaining intensity was scored semi-quantitatively on a three-tiered scale (negative = –, weakly positive = +, strongly positive = ++) relative to the known positive and negative controls

Funtion Uniprot: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain

UniProt ID: Q9UIQ6

UniProt Link: https://www.uniprot.org/uniprotkb/Q9UIQ6/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.

Subcellular UniProt: #Cell membrane #Membrane #Secreted

Alternative name from UniProt:

Cleaved: Cleaved into 1 chains Leucyl-cystinyl aminopeptidase, pregnancy serum form

Catalytic activity: Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however

Recommended name: Leucyl-cystinyl aminopeptidase

Gene name from HGNC: LNPEP (CAP, IRAP, P-LAP, PLAP)

HPA class: Enzymes

AlphaFold DB: Q9UIQ6

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9UIQ6

HPA link: https://www.proteinatlas.org/ENSG00000113441-LNPEP

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic expression in most tissues with additional plasma positivity in several tissues.

Single cell type specificity Cell type enhanced (NK-cells)

Immune cell specificity: Low immune cell specificity

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000113441-LNPEP/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000113441-LNPEP/pathology/endometrial+cancer

OMIM: 151300

OMIM link2: https://www.omim.org/entry/151300

HGNC ID: HGNC:6656

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6656