Biomarker: ATP7B

Histology type: endometrioid endometrial carcinoma

Country: Japan

Region: Hikarigaoka

Followed up time :

Subgroup 1 name : Negative

Subgroup 1 number: 32

Subgroup 2 name: Positive

Subgroup 2 number: 19

Conclusion: These findings suggest that overexpression of ATP7B expression in endometrial carcinoma is correlated with unfavorable clinical outcome in patients treated with cisplatin-based chemotherapy. ATP7B expression could be considered as a prognostic factor in patients with endometrial carcinoma.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : cytoplasmic overexpression(>10%)

Expression elevation: If more than 10% of the tumor cells were stained, the samples were considered to be ATP7B-positive carcinomas

Statictics: Mean ;Range

Subgroup 1 age: 57.4;26–79

Subgroup 2 age: 59.2;37–76

Funtion Uniprot: Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.

UniProt ID: P35670

UniProt Link: https://www.uniprot.org/uniprotkb/P35670/entry

Biological function from UniProt: #Copper transport #Ion transport #Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.

Subcellular UniProt: #Cytoplasm #Endosome #Golgi apparatus #Membrane #Mitochondrion

Alternative name from UniProt:

Cleaved: Cleaved into 1 chains WND/140 kDa

Catalytic activity: ATP + Cu+(in) + H2O = ADP + Cu+(out) + H+ + phosphate

Recommended name: Copper-transporting ATPase 2

Gene name from HGNC: ATP7B (WND)

HPA class: Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets Transporters

AlphaFold DB: P35670

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P35670

HPA link: https://www.proteinatlas.org/ENSG00000123191-ATP7B

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Granular cytoplasmic expression in most tissues.

Single cell type specificity Cell type enhanced (Late spermatids, Early spermatids, Inhibitory neurons, Excitatory neurons, Hepatocytes, Cone photoreceptor cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Golgi apparatus (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in endometrial cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000123191-ATP7B/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000123191-ATP7B/pathology/endometrial+cancer

Phenotype ID: 277900

Disease: Wilson disease (WD)

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 606882

OMIM link1: https://www.omim.org/entry/277900

OMIM link2: https://www.omim.org/entry/606882

HGNC ID: HGNC:870

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:870