Biomarker: skp2

Histology type: endometrioid endometrial carcinoma

Country: Japan

Region: Kanagawa

Study type: Comparative Study

Followed up time :

Conclusion: The skp2 level might have increased due to p27 accumulation and may be a good indicator of proliferative activity and poor prognosis.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high expression（(LI≥20%）

Expression elevation: Positive staining was evaluated by counting approximately 1,000 cells in high-power fields and was expressed as the labeling index (LI), which was regarded as the percentage of positive nuclei.

Statictics: Median;Range

Cohort age: 57;30-83

Funtion Uniprot: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219).Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.

UniProt ID: Q13309

UniProt Link: https://www.uniprot.org/uniprotkb/Q13309/entry

Biological function from UniProt: #Antiviral defense #Host-virus interaction #Immunity #Innate immunity #Ubl conjugation pathway

Molecular function from UniProt:

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Recommended name: S-phase kinase-associated protein 2

Gene name from HGNC: SKP2 (FBL1, FBXL1, p45)

HPA class: Cancer-related genes

AlphaFold DB: Q13309

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q13309

HPA link: https://www.proteinatlas.org/ENSG00000145604-SKP2

Tissue specificity RNA from HPA: Tissue enhanced (placenta)

Tissue expression from HPA: Nuclear and cytoplasmic expression in placenta.

Single cell type specificity Group enriched (Extravillous trophoblasts, Cytotrophoblasts, Syncytiotrophoblasts)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Cytosol (CCD Transcript)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), melanoma (unfavorable) and ovarian cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000145604-SKP2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000145604-SKP2/pathology/endometrial+cancer

OMIM: 601436

OMIM link2: https://www.omim.org/entry/601436

HGNC ID: HGNC:10901

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10901