Biomarker: 14-3-3sigma

Histology type: endometrial carcinoma

Stage: early stage

Country: Japan

Region: Sendai

Study type: Comparative Study

Followed up time :

Subgroup 1 name : Positive

Subgroup 1 number: 78

Subgroup 2 name: Negative

Subgroup 2 number: 25

Conclusion: 14-3-3sigma in endometrial cancer--a possible prognostic marker in early-stage cancer

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : loss or absence

Expression elevation: As immunoreactivities of 14-3-3sigma were relatively homogeneous and clearly distinguishable as positive or negative, carcinoma cells were classified into the two groups without much differently (+, carcinoma cells with positive immunoreactivity; , carcinoma cells with no immunoreactivity) by two of the same authors above

Funtion Uniprot: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. p53-regulated inhibitor of G2/M progression

UniProt ID: P31947

UniProt Link: https://www.uniprot.org/uniprotkb/P31947/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Subcellular UniProt: #Cytoplasm #Nucleus #Secreted

Alternative name from UniProt:

Recommended name: 14-3-3 protein sigma

Gene name from HGNC: SFN (YWHAS)

HPA class: Cancer-related genes Plasma proteins

AlphaFold DB: P31947

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P31947

HPA link: https://www.proteinatlas.org/ENSG00000175793-SFN

Tissue specificity RNA from HPA: Group enriched (esophagus, skin, vagina)

Tissue expression from HPA: High cytoplasmic expression in squamous epithelia and lower expression in a few other cell types such as urothelia, prostate and respiratory epithelia.

Single cell type specificity Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Squamous epithelial cells, Urothelial cells, Basal prostatic cells)

Immune cell specificity: Immune cell enriched (basophil)

Subcellular summary HPA Located in Cytosol (CCD Transcript)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), liver cancer (unfavorable), endometrial cancer (favorable) and pancreatic cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000175793-SFN/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000175793-SFN/pathology/endometrial+cancer

Expression figure legend: Immunohistochemistry of 14-3-3σ expression

Expression figure link: https://aacrjournals.org/view-large/figure/9143715/05-0187f01c.jpeg

Survival figure legend: A, correlation between 14-3-3σ immunoreactivity and recurrence for patients with endometrial cancer. B, correlation between 14-3-3σ immunoreactivity and survival for patients with endometrial cancer.

Survival curve link: https://aacrjournals.org/view-large/figure/9143720/05-0187f02l.jpeg

OMIM: 601290

OMIM link2: https://www.omim.org/entry/601290

HGNC ID: HGNC:10773

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10773