Biomarker: cyclin H

Histology type: benign tumor

Country: Turkey

Region: Adana

Study type: Comparative Study

Followed up time :

Conclusion: It might be one of the biomarkers for determining proliferative activity in endometrial hyperplasia and endometrioid adenocarcinoma.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Expression elevation: Every stained slide was assessed and given a score in which the intensity of the staining (no staining = 0, weak staining =1, medium staining = 2, and strong staining= 3) and the percentage of stained cells (0% = 0, 1–24% = 1, 25–49% = 2, 50–74% = 3, and greater than 75% = 4) were multiplied. With the system, the maximum score was 12 (with over 75% of the cells showing strong staining) and the minimum score was 0 (negative staining).Data were expressed as mean ± SD, median (minimum to maximum), n (number of cases), and percentage (%). Bonferroni’s correction was applied (P <0.05/n, where n - number of comparisons) when multiple comparisons were made

Funtion Uniprot: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

UniProt ID: P51946

UniProt Link: https://www.uniprot.org/uniprotkb/P51946/entry

Biological function from UniProt: #Cell cycle #Transcription #Transcription regulation

Molecular function from UniProt:

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: Cyclin-H

Gene name from HGNC: CCNH (CycH, p34, p37)

HPA class: Cancer-related genes

AlphaFold DB: P51946

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P51946

HPA link: https://www.proteinatlas.org/ENSG00000134480-CCNH

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Nuclear expression in several tissues.

Single cell type specificity Cell type enhanced (Early spermatids, Plasma cells, T-cells, Spermatocytes)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable) and ovarian cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000134480-CCNH/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000134480-CCNH/pathology/endometrial+cancer

OMIM: 601953

OMIM link2: https://www.omim.org/entry/601953

HGNC ID: HGNC:1594

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1594