Basic information
Biomarker: alpha-catenin
Histology type: endometrial carcinoma
Cohort characteristics
Country: Netherlands
Region: Leiden
Followed up time :
Subgroup 1 name : positive
Subgroup 1 number: 120
Subgroup 2 name: negative
Subgroup 2 number: 105
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 225 | EC | 225 |
Sample information
Conclusion: Combined positive E-cadherin, alpha-catenin, and beta-catenin expression was a significant prognostic factor.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : expression
Expression elevation: Slides were scored for the intensity of the membranous staining of alpha-catenin staining intensity (SI) and for the proportion of positive tumor cells (PTCs) according to a scoring system that has been used previously by Moreno-Bueno et al.(12) The SI could vary from 0 (absent), 1 (weak), 2 (moderate) to 3 (strong, as in normal endometrium) (Fig. 1). The PTCs varied from 0 (0%), 1 (1–25%), 2 (26–50%), 3 (51–75%) to 4 (.75%). The degree of membranous staining, the staining score, was calculated as the sum of SI and PTCs (range 0–7).
Disease information
Related information
UniProt Link: https://www.uniprot.org/uniprotkb?query=alpha-catenin
Molecular function from UniProt:
HGNC link: https://www.genenames.org/tools/search/#!/?query=alpha-catenin
