Biomarker: E-cadherin

Histology type: endometrial carcinoma

Country: Netherlands

Region: Leiden

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 125

Subgroup 2 name: negative

Subgroup 2 number: 100

Conclusion: Combined positive E-cadherin, alpha-catenin, and beta-catenin expression was a significant prognostic factor.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Expression elevation: Slides were scored for the intensity of the membranous staining of E-cadherin staining intensity (SI) and for the proportion of positive tumor cells (PTCs) according to a scoring system that has been used previously by Moreno-Bueno et al.(12) The SI could vary from 0 (absent), 1 (weak), 2 (moderate) to 3 (strong, as in normal endometrium) (Fig. 1). The PTCs varied from 0 (0%), 1 (1–25%), 2 (26–50%), 3 (51–75%) to 4 (.75%). The degree of membranous staining, the staining score, was calculated as the sum of SI and PTCs (range 0–7).

Funtion Uniprot: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-72 Publications E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.1 Publication (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.3 Publications

UniProt ID: P12830

UniProt Link: https://www.uniprot.org/uniprotkb/P12830/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Non-neural epithelial tissues.

Subcellular UniProt: #Cell junction #Cell membrane #Endosome #Golgi apparatus #Membrane

Alternative name from UniProt:

Recommended name: Cadherin-1

Gene name from HGNC: CDH1 (CD324, UVO, uvomorulin)

HPA class: Cancer-related genes CD markers Disease related genes Human disease related genes Plasma proteins

AlphaFold DB: P12830

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P12830

Induction: Expression is repressed by MACROD1.

HPA link: https://www.proteinatlas.org/ENSG00000039068-CDH1

Tissue specificity RNA from HPA: Tissue enhanced (parathyroid gland)

Tissue expression from HPA: Cytoplasmic and membranous expression in epithelial cells.

Single cell type specificity Cell type enhanced (Distal enterocytes, Glandular and luminal cells, Pancreatic endocrine cells)

Immune cell specificity: Group enriched (plasmacytoid DC, myeloid DC)

Subcellular summary HPA Located in Golgi apparatus, Plasma membrane, Cell Junctions (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000039068-CDH1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000039068-CDH1/pathology/endometrial+cancer

Phenotype ID: 137215;608089

Disease: Hereditary diffuse gastric cancer (HDGC);Endometrial cancer (ENDMC)| Ovarian cancer (OC)|Breast cancer, lobular (LBC)|Blepharocheilodontic syndrome 1 (BCDS1)

Note1: Disease susceptibility is associated with variants affecting the gene represented in this entry. Heterozygous CDH1 germline mutations are responsible for familial cases of diffuse gastric cancer. Somatic mutations has also been found in patients with sporadic diffuse gastric cancer and lobular breast cancer;Disease susceptibility is associated with variants affecting the gene represented in this entry| Disease susceptibility is associated with variants affecting the gene represented in this entry |The gene represented in this entry may be involved in disease pathogenesis |The disease is caused by variants affecting the gene represented in this entry|

OMIM: 192090

OMIM link1: https://www.omim.org/entry/137215|https://www.omim.org/entry/608089|https://www.omim.org/entry/137215|https://www.omim.org/entry/119580

OMIM link2: https://www.omim.org/entry/192090

HGNC ID: HGNC:1748

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1748