Biomarker: RCAS1

Histology type: endometrial carcinoma

Country: Japan

Region: Fukuoka

Followed up time :

Subgroup 1 name : EC

Subgroup 1 number: 50

Subgroup 2 name: Cervical cancer

Subgroup 2 number: 63

Conclusion: RCAS1 may be a biomarker of uterine cancer because of its potential to predict results of uterine cancer treatment and inhibit growth of immune cells.

Sample type : serum

Sample method: ELISA/Tetrazolium salt (WST-1) assay/Immunodepletion of RCAS1

Expression pattern : higher serum level

Statictics: Mean (SD)

Subgroup 1 age: 51 ± 16

Subgroup 2 age: 56 ± 11

Funtion Uniprot: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

UniProt ID: O00559

UniProt Link: https://www.uniprot.org/uniprotkb/O00559/entry

Biological function from UniProt: #Apoptosis

Molecular function from UniProt:

Tissue specificity from UniProt: Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.

Subcellular UniProt: #Golgi apparatus #Membrane

Alternative name from UniProt:

Caution: It was initially reported to be a ligand for some putative receptor present on T-, B-, natural killer (NK) cells and various human cell lines. However, PubMed:12672804 showed that it does not bind any receptor.

Miscellaneous: May serve as a prognostic marker for cancers such as adenocarcinomas of the lung and breast cancers. It is present and overexpressed in many patients suffering from breast carcinomas, its level of expression correlates with tumor grade, suggesting that it may be involved in cancer immune escape. According to PubMed:12672804, it is however not directly a tumor-associated antigen, but it rather modulates surface expression of tumor-associated O-linked glycan Tn when it is overexpressed, suggesting that it contributes indirectly to the antigenicity of tumor cells.

Recommended name: Receptor-binding cancer antigen expressed on SiSo cells

Gene name from HGNC: EBAG9 (EB9, RCAS1)

HPA class: Cancer-related genes

AlphaFold DB: O00559

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O00559

Induction: By estrogen.

HPA link: https://www.proteinatlas.org/ENSG00000147654-EBAG9

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Ubiquitous cytoplasmic expression with a granular pattern.

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Golgi apparatus

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000147654-EBAG9/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000147654-EBAG9/pathology/endometrial+cancer

OMIM: 605772

OMIM link2: https://www.omim.org/entry/605772

HGNC ID: HGNC:3123

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3123