Biomarker: GLUT8

Histology type: endometrioid endometrial carcinoma

Stage: grade

Country: USA

Region: NY

Study type: Comparative Study

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 65

Subgroup 2 name: negative

Subgroup 2 number: 0

Conclusion: GLUT8 may be important marker in tumor differentiation, as well as providing energy to rapidly dividing tumor cells.

Sample type : tissue

Sample method: Immunoblot and immunolocatization studies,Immunofluoresence

Expression pattern : upregulation

Funtion Uniprot: Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.

UniProt ID: Q9NY64

UniProt Link: https://www.uniprot.org/uniprotkb/Q9NY64/entry

Biological function from UniProt: #Sugar transport #Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.

Subcellular UniProt: #Cell membrane #Cytoplasmic vesicle #Membrane

Alternative name from UniProt:

Catalytic activity: D-glucose(out) = D-glucose(in),D-fructose(out) = D-fructose(in),L-dehydroascorbate(out) = L-dehydroascorbate(in),

Activity regulation: Inhibited by cytochalasin B.

Recommended name: Solute carrier family 2, facilitated glucose transporter member 8

Gene name from HGNC: SLC2A8 (GLUT8, GLUTX1)

HPA class: Metabolic proteins Transporters

AlphaFold DB: Q9NY64

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9NY64

Induction: In testis, down-regulated by estrogen.

HPA link: https://www.proteinatlas.org/ENSG00000136856-SLC2A8

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Low cytoplasmic expression in a few tissues, highly abundant in testis.

Single cell type specificity Cell type enhanced (Late spermatids, Early spermatids, Spermatocytes, Endometrial stromal cells)

Immune cell specificity: Immune cell enriched (plasmacytoid DC)

Subcellular summary HPA Located in Vesicles

Cancer prognostic summary HPA Prognostic marker in cervical cancer (favorable), renal cancer (favorable) and pancreatic cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000136856-SLC2A8/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000136856-SLC2A8/pathology/endometrial+cancer

Expression figure legend: Immunolocalization of GLUT8 in endometrial tissue and endometrial adenocarcinoma.

Expression figure link: https://www.nature.com/articles/3800656/figures/3

OMIM: 605245

OMIM link2: https://www.omim.org/entry/605245

HGNC ID: HGNC:13812

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13812