Biomarker: YKL-40

Histology type: endometrial carcinoma

Stage: high risk

Country: USA

Region: New York

Followed up time :

Subgroup 1 name : >61 ng/mL

Subgroup 1 number: 26

Subgroup 2 name: <61 ng/m

Subgroup 2 number: 8

Conclusion: Preoperative serum YKL-40 is frequently elevated and may represent a novel marker for the detection of endometrial cancer and the identification of high-risk subsets of patients with worse clinical outcome. Further investigation of this promising endometrial cancer marker in larger studies is warranted.

Sample type : serum

Sample method: ELISA

Expression pattern : 80 ng/mL and 61 ng/mL

Funtion Uniprot: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

UniProt ID: P36222

UniProt Link: https://www.uniprot.org/uniprotkb/P36222/entry

Biological function from UniProt: Apoptosis, Inflammatory response

Molecular function from UniProt:

Tissue specificity from UniProt: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.

Subcellular UniProt: #Cytoplasm #Endoplasmic reticulum #Secreted

Alternative name from UniProt:

Gene name from HGNC: CHI3L1 (GP39, YK-40, YKL40)

Induction: Up-regulated in colon under several inflammatory conditions. Down-regulated by hyperoxia in bronchial epithelial cells.

HPA link: https://www.proteinatlas.org/ENSG00000133048-CHI3L1

Tissue specificity RNA from HPA: Tissue enhanced (bone marrow, brain, liver)

Subcellular summary HPA Located in Golgi apparatus, Vesicles

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000133048-CHI3L1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000133048-CHI3L1/pathology/endometrial+cancer

Disease: Asthma-related traits 7 (ASRT7);Schizophrenia (SCZD)

Note1: Disease susceptibility is associated with variants affecting the gene represented in this entry;Disease susceptibility is associated with variants affecting the gene represented in this entry;

Note2: Disease susceptibility is associated with variants affecting the gene represented in this entry;Disease susceptibility is associated with variants affecting the gene represented in this entry;

OMIM: 611960;181500;601525

OMIM link1: https://www.omim.org/entry/611960;https://www.omim.org/entry/181500;

OMIM link2: https://www.omim.org/entry/611960;https://www.omim.org/entry/181500;

Phenotype: Asthma-related traits 7 (ASRT7);Schizophrenia (SCZD)

HGNC ID: HGNC:1932

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1932