Biomarker: ephrinB2

Histology type: endometrial carcinoma

Country: Japan

Region: Gifu City

Followed up time :

Conclusion: EphrinB2 and EphB4 were overexpressed during the tumor advancement as dedifferentiation and myometrial invasion. Therefore, ephrinB2/EphB4 might work on tumor advancement and may be recognized as a novel prognostic indicator for uterine endometrial cancers.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : Overexpression

Expression elevation: Intensities were classified as 0 (no staining), 1 (weak staining), 2 (distinct staining), 3 (strong staining) and 4 (very strong staining).

Funtion Uniprot: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.

UniProt ID: P52799

UniProt Link: https://www.uniprot.org/uniprotkb/P52799/entry

Biological function from UniProt: #Angiogenesis #Differentiation #Host-virus interaction #Neurogenesis

Molecular function from UniProt:

Tissue specificity from UniProt: Lung and kidney.

Subcellular UniProt: #Cell junction #Cell membrane #Membrane

Alternative name from UniProt:

Recommended name: Ephrin-B2

Gene name from HGNC: EFNB2 (EPLG5, Htk-L, HTKL, LERK5, MGC126226, MGC126227, MGC126228)

HPA class: Cancer-related genes Plasma proteins

AlphaFold DB: P52799

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P52799

HPA link: https://www.proteinatlas.org/ENSG00000125266-EFNB2

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: General cytoplasmic expression.

Single cell type specificity Cell type enhanced (Adipocytes, Hepatic stellate cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm, Cytosol

Cancer prognostic summary HPA Prognostic marker in head and neck cancer (unfavorable), pancreatic cancer (unfavorable) and lung cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000125266-EFNB2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000125266-EFNB2/pathology/endometrial+cancer

OMIM: 600527

OMIM link2: https://www.omim.org/entry/600527

HGNC ID: HGNC:3227

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3227