Biomarker: CD24

Histology type: endometrial carcinoma

Stage: aggressive endometrial cancer

Country: Turkey

Region: Isparta

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 34

Subgroup 2 name: negative

Subgroup 2 number: 10

Conclusion: Our data suggests that CD24 expression in endometrial carcinoma as detected by immunohistochemistry might be a new marker for a more aggressive endometrial cancer biology. CD24 is commonly up-regulated in endometrial cancer and this corroborates the importance of CD24 in tumor progression among these cases.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : Cytoplasmic and membranous expression

Expression elevation: Cytoplasmic and membranous immunoreactivity were scored semiquantitatively by Fisher's exact test.

Funtion Uniprot: May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).

UniProt ID: P25063

UniProt Link: https://www.uniprot.org/uniprotkb/P25063/entry

Molecular function from UniProt:

Tissue specificity from UniProt: B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.

Subcellular UniProt: #Cell membrane #Membrane

Alternative name from UniProt:

Recommended name: Signal transducer CD24

Gene name from HGNC: CD24 (CD24A)

CD antigen name: CD24

HPA class: Cancer-related genes CD markers Disease related genes

AlphaFold DB: P25063

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P25063

Induction: Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.

HPA link: https://www.proteinatlas.org/ENSG00000272398-CD24

Tissue specificity RNA from HPA: Tissue enhanced (thyroid gland)

Tissue expression from HPA: Cytoplasmic expression in most tissues.

Single cell type specificity Cell type enhanced (Exocrine glandular cells, Pancreatic endocrine cells, Distal tubular cells, Distal enterocytes, Glandular and luminal cells)

Immune cell specificity: Group enriched (eosinophil, memory B-cell, naive B-cell)

Subcellular summary HPA Located in Vesicles (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in breast cancer (unfavorable), colorectal cancer (favorable) and liver cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000272398-CD24/pathology

Phenotype ID: 126200

Disease: Multiple sclerosis (MS)

Note1: Disease susceptibility may be associated with variants affecting the gene represented in this entry

Note2: A number sign (#) is used with this entry because of evidence that susceptibility to multiple sclerosis-1 (MS1) is associated with variation in certain HLA genes on chromosome 6p21, including HLA-A (142800), HLA-DRB1 (142857), HLA-DQB1 (604305), HLA-DRA (142860), on chromosome 6p21.3.

OMIM: 600074;126200;

OMIM link1: https://www.omim.org/entry/126200

OMIM link2: https://www.omim.org/entry/600074

Phenotype: MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO

HGNC ID: HGNC:1645

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1645