Biomarker: BNIP3

Histology type: endometrial carcinoma

Country: Greece

Region: Alexandroupolis

Followed up time :

Subgroup 1 name : overexpression

Subgroup 1 number: 23

Subgroup 2 name: Low expression

Subgroup 2 number: 49

Conclusion: BNIP3 seems to be an important hypoxia-regulated molecule involved in endometrial cancer pathology. Given that high BNIP3 reactivity, being linked with poor post-operative outcome, has been linked with a favourable response to cytotoxic therapy (as previously indicated in experimental studies), high BNIP3 expression may be an indicator for adjuvant chemoradiotherapy in stage I endometrial carcinomas.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : overexpression

Expression elevation: The percentage of cancer cells with cytoplasmic BNIP3 reactivity was recorded after inspection of all fields in the tissue sample. The percentage of positive cells was recorded in each individual field and the final score for each case was the median value obtained.

Funtion Uniprot: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

UniProt ID: Q12983

UniProt Link: https://www.uniprot.org/uniprotkb/Q12983/entry

Biological function from UniProt: #Apoptosis #Host-virus interaction

Molecular function from UniProt:

Subcellular UniProt: #Membrane #Mitochondrion #Mitochondrion outer membrane

Recommended name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Gene name from HGNC: BNIP3 (Nip3)

HPA class: Cancer-related genes

AlphaFold DB: Q12983

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q12983

HPA link: https://www.proteinatlas.org/ENSG00000176171-BNIP3

Tissue specificity RNA from HPA: Tissue enhanced (pancreas, skeletal muscle)

Tissue expression from HPA: Nuclear and cytoplasmic expression in placenta.

Single cell type specificity Cell type enhanced (Proximal tubular cells, Extravillous trophoblasts, Hepatocytes)

Immune cell specificity: Low immune cell specificity

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000145604-SKP2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000145604-SKP2/pathology/endometrial+cancer

OMIM: 603293

OMIM link2: https://www.omim.org/entry/603293

HGNC ID: HGNC:1084

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1084