Biomarker: folate receptor alpha

Histology type: rare type

Study type: Multicenter Study

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 40

Subgroup 2 name: negative

Subgroup 2 number: 6

Conclusion: Our study shows expression of FRA in the carcinomatous component of almost all CS（Carcinosarcomas cases） (87%), further favoring FRA as a target for adjuvant treatment

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : overexpression

Funtion description: Folate plays a role in tumor cell migration and loss of cellular adhesion, which are key steps in epithelial-mesenchymal transition, the process by which CS develops from carcinoma cells.

Funtion Uniprot: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728, PubMed:19074442). Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728). Required for normal embryonic development and normal cell proliferation (By similarity).

UniProt ID: P15328

UniProt Link: https://www.uniprot.org/uniprotkb/P15328/entry

Biological function from UniProt: Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.

Subcellular UniProt: #Cell membrane #Cytoplasmic vesicle #Endosome #Membrane #Secreted

Alternative name from UniProt:

Recommended name: Folate receptor alpha

Gene name from HGNC: FOLR1 (FOLR, FRα)

HPA class: Disease related genes Human disease related genes Metabolic proteins Potential drug targets Transporters

AlphaFold DB: P15328

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P15328

HPA link: https://www.proteinatlas.org/ENSG00000110195-FOLR1

Tissue specificity RNA from HPA: Tissue enhanced (choroid plexus, fallopian tube, lung, salivary gland)

Single cell type specificity Cell type enhanced (Endometrial stromal cells, Fibroblasts, Smooth muscle cells, Langerhans cells, Theca cells)

Immune cell specificity: Mammary glandular cells - Lactation (mainly)

Subcellular summary HPA Located in Nuclear membrane (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in liver cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000110195-FOLR1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000110195-FOLR1/pathology/endometrial+cancer

Phenotype ID: 613068

Disease: Neurodegeneration due to cerebral folate transport deficiency (NCFTD)

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 136430;

OMIM link1: https://www.omim.org/entry/613068

OMIM link2: https://www.omim.org/entry/136430

HGNC ID: HGNC:3791

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3791