Basic information
Biomarker: IMP3
Histology type: endometrial serous carcinomas
Cohort characteristics
Country: USA
Region: MA
Followed up time :
Subgroup 1 name : Positive in EC
Subgroup 1 number: 99
Subgroup 2 name: negative in EC
Subgroup 2 number: 68
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 187 | endometrioid adenocarcinoma | 122 | serous carcinoma (ESC) | 45 | benign endometriums | 20 |
Sample information
Conclusion: Expression of IMP3 may be helpful biomarkers in the distinction of endometrial serous carcinoma from endometrioid adenocarcinoma.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : expression
Expression elevation: The percentage of endometrioid adenocarcinoma, serous carcinoma, or normal endometrium that was positive for IMP3 was assessed. The intensity of the staining was evaluated as weak, intermediate, or strong.
Disease information
Statictics: Range
Cohort age: 34-58
Related information
Funtion Uniprot: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
UniProt ID: Q9NV31
UniProt Link: https://www.uniprot.org/uniprotkb/Q9NV31/entry
Biological function from UniProt: Ribosome biogenesis, rRNA processing
Molecular function from UniProt:
Subcellular UniProt: Nucleus
Alternative name from UniProt:
Recommended name: U3 small nucleolar ribonucleoprotein protein IMP3
Gene name from HGNC: IMP3 (BRMS2, C15orf12, FLJ10968, MRPS4)
HPA class: Plasma proteins Ribosomal proteins
AlphaFold DB: Q9NV31
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9NV31
HPA link: https://www.proteinatlas.org/ENSG00000177971-IMP3
Tissue specificity RNA from HPA: Low tissue specificity
Single cell type specificity Low cell type specificity
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA Located in Nucleoplasm, Nucleoli (Single cell variability)
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000177971-IMP3/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000177971-IMP3/pathology/endometrial+cancer
Expression figure legend: expression of IMP3
Expression figure link: https://www.nature.com/articles/3800960/figures/1
OMIM: 612980
OMIM link2: https://www.omim.org/entry/612980
HGNC ID: HGNC:14497
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14497
