Basic information
Biomarker: CRP
Histology type: endometrial carcinoma
Cohort characteristics
Region: Vienna;Klagenfurt/Innsbruck
Study type: multicenter study
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 403 | Patients With no Evidence of Disease at Last Observation | 357 | Patients With Progressive Disease/ Cancer-Related Death at Last Observation | 46 |
Sample information
Conclusion: Our results suggest that elevated serum CRP levels are associated with a less favorable prognosis in patients with surgically treated endometrial cancer.
Sample type : serum
Sample method: ELISA
Expression pattern : > 0.5 mg/dL
Disease information
Related information
Funtion Uniprot: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
UniProt ID: P02741
UniProt Link: https://www.uniprot.org/uniprotkb/P02741/entry
Biological function from UniProt: #Acute phase
Molecular function from UniProt:
Tissue specificity from UniProt: Found in plasma.
Subcellular UniProt: #Secreted
Cleaved: Cleaved into 1 chains C-reactive protein(1-205)
Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.
Recommended name: C-reactive protein
Gene name from HGNC: CRP (PTX1)
HPA class: Cancer-related genes Candidate cardiovascular disease genes Human disease related genes Plasma proteins
AlphaFold DB: P02741
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P02741
Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6/interleukin-6.
HPA link: https://www.proteinatlas.org/ENSG00000132693-CRP
Tissue specificity RNA from HPA: Tissue enriched (liver)
Tissue expression from HPA: Extracellular deposits in several tissues. Cytoplasmic expression in liver.
Single cell type specificity Group enriched (Hepatocytes, Ductal cells)
Immune cell specificity: Not detected in immune cells
Subcellular summary HPA Located in Nucleoplasm, Vesicles, Intermediate filaments
Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000132693-CRP/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000132693-CRP/pathology/endometrial+cancer
OMIM: 123260
OMIM link2: https://www.omim.org/entry/123260
HGNC ID: HGNC:2367
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2367
