Biomarker: IMP3

Histology type: endometrial clear cell carcinoma

Country: USA

Region: NC

Followed up time :

Conclusion: Strong and diffuse IMP3 expression is highly sensitive for endometrial clear cell carcinomas including their putative precursor lesions

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : strong and diffuse

Expression elevation: The percentage of neoplastic cells and nonneoplastic tissues that showed dark brown cytoplasmic staining was recorded. The intensity of the IHC staining was recorded as absent, weak, moderate, or strong.

Funtion Uniprot: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

UniProt ID: Q9NV31

UniProt Link: https://www.uniprot.org/uniprotkb/Q9NV31/entry

Biological function from UniProt: Ribosome biogenesis, rRNA processing

Molecular function from UniProt:

Subcellular UniProt: Nucleus

Alternative name from UniProt:

Recommended name: U3 small nucleolar ribonucleoprotein protein IMP3

Gene name from HGNC: IMP3 (BRMS2, C15orf12, FLJ10968, MRPS4)

HPA class: Plasma proteins Ribosomal proteins

AlphaFold DB: Q9NV31

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9NV31

HPA link: https://www.proteinatlas.org/ENSG00000177971-IMP3

Tissue specificity RNA from HPA: Low tissue specificity

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Nucleoli (Single cell variability)

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000177971-IMP3/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000177971-IMP3/pathology/endometrial+cancer

OMIM: 612980

OMIM link2: https://www.omim.org/entry/612980

HGNC ID: HGNC:14497

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14497