Biomarker: aquaporin-1 (AQP1)

Histology type: endometrioid endometrial carcinoma

Country: China

Region: Zhejiang

Followed up time :

Conclusion: AQP1 level may be both a tumor indicator and a new therapeutic target.

Sample type : tissue

Sample method: immunohistochemistry/RT-PCR

Expression pattern : AQP1/IMD ratio

Expression elevation: The mean value of vessel number visualized at high magnification (×400) in 5 fields within the hot spot defined IMD.The number of microvessels observed varies by tumor and vascular spot, resulting in an error in any measurement of AQP1 expression. To decrease this error, AQP1 expression in the microvessels was represented by the AQP1/IMD ratio.

Statictics: Median

Cohort age: 54;41

Funtion description: AQP1 may be involved in the tumorigenesis and progression of endometrioid adenocarcinoma by promoting angiogenesis

Funtion Uniprot: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

UniProt ID: P29972

UniProt Link: https://www.uniprot.org/uniprotkb/P29972/entry

Biological function from UniProt: #Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.

Subcellular UniProt: #Cell membrane #Membrane

Alternative name from UniProt:

Miscellaneous: Pharmacologically inhibited by submillimolar concentrations of mercury.

Recommended name: Aquaporin-1

Gene name from HGNC: AQP1 (CHIP28, CO)

HPA class: Blood group antigen proteins Metabolic proteins Transporters

AlphaFold DB: P29972

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P29972

HPA link: https://www.proteinatlas.org/ENSG00000240583-AQP1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Selective membranous expression in renal tubules, exocrine pancreas, bile ducts, subsets of cells in the intestine, myoepithelial cells of breast and endothelial cells.

Single cell type specificity Cell type enhanced (Adipocytes, Endothelial cells, Cholangiocytes, Hepatic stellate cells, Proximal tubular cells, Alveolar cells type 2)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Plasma membrane

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable) and head and neck cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000240583-AQP1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000240583-AQP1/pathology/endometrial+cancer

Note2: A number sign (#) is used with this entry because of evidence that Colton blood group is due to variation in the aquaporin-CHIP gene (AQP1; 107776) on chromosome 7p14.

OMIM: 107776;110450;

OMIM link2: https://www.omim.org/entry/107776;https://www.omim.org/entry/110450;

Phenotype: BLOOD GROUP, COLTON SYSTEM

HGNC ID: HGNC:633

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:633