Basic information
Biomarker: ADAM19
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Beijing
Followed up time :
Subgroup 1 name : low expression in normal
Subgroup 1 number: 23
Subgroup 2 name: High expression in normal control
Subgroup 2 number: 10
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 84 | EC | 51 | normal endometrium | 33 |
Sample information
Conclusion: The overexpression of ADAM19 suggests that ADAM19 correlates with the progress and prognosis of endometrial carcinoma, and may be implicated as a marker for the clinical behavior of endometrial carcinoma.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : overexpression
Disease information
Related information
Funtion Uniprot: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)
UniProt ID: Q9H013
UniProt Link: https://www.uniprot.org/uniprotkb/Q9H013/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed in many normal organ tissues and several cancer cell lines.
Subcellular UniProt: #Membrane
Alternative name from UniProt:
Recommended name: Disintegrin and metalloproteinase domain-containing protein 19
Gene name from HGNC: ADAM19 (MLTNB)
HPA class: Plasma proteins
AlphaFold DB: Q9H013
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9H013
Induction: By 1,25(OH)2VD3 in monocytes.
HPA link: https://www.proteinatlas.org/ENSG00000135074-ADAM19
Tissue specificity RNA from HPA: Low tissue specificity
Single cell type specificity Cell type enhanced (monocytes, Extravillous trophoblasts, Cone photoreceptor cells, B-cells, Plasma cells, Langerhans cells, Rod photoreceptor cells)
Immune cell specificity: Group enriched (eosinophil, basophil, neutrophil, plasmacytoid DC, naive B-cell, memory B-cell)
Subcellular summary HPA Located in Vesicles
Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000135074-ADAM19/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000135074-ADAM19/pathology/endometrial+cancer
OMIM: 603640
OMIM link2: https://www.omim.org/entry/603640
HGNC ID: HGNC:197
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:197
