Biomarker: BMI-1

Histology type: endometrial carcinoma

Country: Norway

Region: Bergen

Study type: prospective study

Followed up time :

Subgroup 1 name : low expression

Subgroup 1 number: 143

Subgroup 2 name: High expression

Subgroup 2 number: 120

Conclusion: Loss of BMI-1 seems to be associated with an aggressive phenotype in endometrial carcinomas.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : Loss expression

Expression elevation: A staining index (SI) was calculated as a product of staining intensity (0–3) and area of positive tumour cell nuclei (1=<10%, 2=10–50%, 3=>50%).Evaluation of the cases was carried out blinded for patient characteristics and outcome. In subsequent statistical analyses, the cut-off was based on the median value for the SI, after considering the frequency distribution curve and the size of subgroups.

Funtion Uniprot: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).

UniProt ID: P35226

UniProt Link: https://www.uniprot.org/uniprotkb/P35226/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.

Recommended name: Polycomb complex protein BMI-1

Gene name from HGNC: BMI1 (PCGF4, RNF51)

HPA class: Cancer-related genes Human disease related genes

AlphaFold DB: P35226

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P35226

Induction: Down-regulated by oxidative stress.

HPA link: https://www.proteinatlas.org/ENSG00000168283-BMI1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: General nuclear expression.

Single cell type specificity Cell type enhanced (Late spermatids, Early spermatids)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Nucleoli, Nuclear bodies, Cytosol

Cancer prognostic summary HPA Prognostic marker in liver cancer (unfavorable

Pathology link: https://www.proteinatlas.org/ENSG00000168283-BMI1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000168283-BMI1/pathology/endometrial+cancer

Expression figure legend: Box plot illustrating correlation between BMI-1 protein expression and mRNA BMI-1 expression.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391115/figure/fig1/

OMIM: 164831

OMIM link2: https://www.omim.org/entry/164831

HGNC ID: HGNC:1066

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1066