Basic information
Biomarker: TFF3
Histology type: endometrioid endometrial carcinoma
Stage: Grade 3
Cohort characteristics
Country: Italy
Region: Brescia
Followed up time :
Subgroup 1 name : low expression(0-1) in EEC
Subgroup 1 number: 22
Subgroup 2 name: high expression(2-3) in EEC
Subgroup 2 number: 0
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 80 | (G3-EEC) | 25 | healthy controls | 42 | endometrial hyperplasia | 13 |
Sample information
Conclusion: In conclusion, TFF3 is highly expressed at gene and protein level in G3-EEC.
Sample type : serum
Sample method: ELISA
Expression pattern : expression
Expression elevation: cutoff=752 ng ml−1
Disease information
Related information
Funtion Uniprot: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).
UniProt ID: Q07654
UniProt Link: https://www.uniprot.org/uniprotkb/Q07654/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level).
Subcellular UniProt: #Cytoplasm #Extracellular matrix #Secreted
Alternative name from UniProt:
Recommended name: Trefoil factor 3
Gene name from HGNC: TFF3 (HITF, ITF)
HPA class: Cancer-related genes Plasma proteins
AlphaFold DB: Q07654
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q07654
HPA link: https://www.proteinatlas.org/ENSG00000160180-TFF3
Tissue specificity RNA from HPA: Group enriched (cervix, intestine, salivary gland, thyroid gland)
Tissue expression from HPA: Distinct expression in mucus secreting cells in gastrointestinal tract, cervix uteri and respiratory epithelia, with secreted positivity in thyroid gland.
Single cell type specificity Cell type enriched (Intestinal goblet cells)
Immune cell specificity: Immune cell enriched (eosinophil)
Subcellular summary HPA Located in Nucleoplasm, Nucleoli (Single cell variability)
Cancer prognostic summary HPA Prognostic marker in endometrial cancer (favorable)
Pathology link: https://www.proteinatlas.org/ENSG00000160180-TFF3/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000160180-TFF3/pathology/endometrial+cancer
OMIM: 600633
OMIM link2: https://www.omim.org/entry/600633
HGNC ID: HGNC:11757
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11757
