Biomarker: progesterone receptor (PR)-A

Histology type: endometrioid endometrial carcinoma

Country: Netherlands

Region: Groningen

Followed up time :

Conclusion: We conclude that in early stage endometrioid endometrial cancer absence of PR-A is an independent prognostic factor for disease-free survival, while patients with ER-alpha positive tumours have a better overall survival.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : absence expression

Expression elevation: The receptor immunoreactivity for ER and PR was semi-quantitatively scored according to the intensity and percentage of tumour cells showing positive nuclear staining, as described previously.Intensity of immunostaining for receptor expression was scored as negative (0), weak (1+), positive (2+) or strongly positive (3+). ER and PR staining was considered positive if nuclear staining in more than 10% of the tumour cells was 2+ or higher

Funtion Uniprot: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.3 PublicationsCurated Isoform A Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.3 Publications2 Publications Isoform B Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.1 Publication Isoform 4 Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

UniProt ID: P06401

UniProt Link: https://www.uniprot.org/uniprotkb/P06401/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli

Subcellular UniProt: #Cytoplasm #Membrane #Mitochondrion #Mitochondrion outer membrane #Nucleus

Alternative name from UniProt:

Recommended name: Progesterone receptor

Gene name from HGNC: PGR (NR3C3, PR)

HPA class: Cancer-related genes FDA approved drug targets Nuclear receptors Transcription factors Transporters

AlphaFold DB: P06401

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P06401

HPA link: https://www.proteinatlas.org/ENSG00000082175-PGR

Tissue specificity RNA from HPA: Group enriched (cervix, endometrium, fallopian tube, smooth muscle)

Tissue expression from HPA: Selective nuclear expression in female reproductive system and smooth muscle.

Single cell type specificity Cell type enhanced (Endometrial stromal cells, Endometrial ciliated cells, Glandular and luminal cells, Early spermatids, Late spermatids)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Prognostic marker in endometrial cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000082175-PGR/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000082175-PGR/pathology/endometrial+cancer

OMIM: 607311

OMIM link2: https://www.omim.org/entry/607311

HGNC ID: HGNC:8910

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8910