Biomarker: osteopontin

Histology type: endometrial carcinoma

Country: Korea

Region: Seoul

Followed up time :

Subgroup 1 name : Positive in EC

Subgroup 1 number: 18

Subgroup 2 name: negative in EC

Subgroup 2 number: 11

Conclusion: By Cox multivariate analysis, osteopontin positivity was an independent prognostic factor for disease-free survival (hazard ratio = 3.18, P= 0.035).

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Expression elevation: Using a score corresponding to the sum of staining intensity and the percentage of positive cells, where strong positive staining in most cells is 3+, moderate staining is 2+, weak staining is 1+, and no evidence of staining is 0, and where more than 50% of cells staining positive is 3+, 5–50% of cells staining positive is 2+, less than 5% of cells staining positive is 1+, and no cells staining positive is 0, respectively

Statictics: Mean (SD)

Subgroup 1 age: 51.3 ± 11.1 years

Subgroup 2 age: 52.3 ± 9.1

Funtion Uniprot: Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

UniProt ID: P10451

UniProt Link: https://www.uniprot.org/uniprotkb/P10451/entry

Biological function from UniProt: #Biomineralization #Cell adhesion

Molecular function from UniProt:

Tissue specificity from UniProt: Bone. Found in plasma.

Subcellular UniProt: #Secreted

Alternative name from UniProt:

Recommended name: Osteopontin

Gene name from HGNC: SPP1 (BNSP, BSPI, ETA-1, OPN)

HPA class: Cancer-related genes Plasma proteins

AlphaFold DB: P10451

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P10451

HPA link: https://www.proteinatlas.org/ENSG00000118785-SPP1

Tissue specificity RNA from HPA: Tissue enhanced (gallbladder, kidney, placenta)

Tissue expression from HPA: Cytoplasmic expression in a subset of tissues, most abundant in renal tubules and gallbladder. Positivity in plasma and extracellular matrix.

Single cell type specificity Cell type enriched (Hofbauer cells)

Immune cell specificity: Immune cell enriched (neutrophil)

Subcellular summary HPA Located in Golgi apparatus

Cancer prognostic summary HPA Prognostic marker in liver cancer (unfavorable), pancreatic cancer (unfavorable) and cervical cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000118785-SPP1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000118785-SPP1/pathology/endometrial+cancer

OMIM: 166490

OMIM link2: https://www.omim.org/entry/166490

HGNC ID: HGNC:11255

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11255