Biomarker: DKK1

Histology type: endometrial carcinoma

Country: China

Region: Beijing

Followed up time :

Subgroup 1 name : low expression in EEC

Subgroup 1 number: 20

Subgroup 2 name: high expression in EEC

Subgroup 2 number: 10

Conclusion: DKK1 is involved in genesis and early phase of EC by suppressing the invasiveness via the Wnt signal pathway. It shows promise as a biomarker for screening the progression of EC.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Expression elevation: Immunohistochemistry staining. Staining was analyzed and scored on the following scale according to percentage of positive expression EC cells: -, <10%; +, 10-25%; ++, 26-50%; +++, >50%. Cases with - or + staining were classified as low expression and cases with ++ or +++ were classified as high expression.

Statictics: Mean ;Range

Cohort age: 59.53;41-78

Funtion description: Exogenous DKK1 suppressed invasiveness of EC cells. Taken together, DKK1 is involved in genesis and early phase of EC by suppressing the invasiveness via the Wnt signal pathway.

Funtion Uniprot: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).

UniProt ID: O94907

UniProt Link: https://www.uniprot.org/uniprotkb/O94907/entry

Biological function from UniProt: #Wnt signaling pathway

Molecular function from UniProt:

Tissue specificity from UniProt: Placenta.

Subcellular UniProt: #Secreted

Alternative name from UniProt:

Recommended name: Dickkopf-related protein 1

Gene name from HGNC: DKK1 (DKK-1, SK)

AlphaFold DB: O94907

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O94907

HPA link: https://www.proteinatlas.org/ENSG00000107984-DKK1

Tissue specificity RNA from HPA: Tissue enhanced (cervix, placenta)

Single cell type specificity Cell type enhanced (Prostatic glandular cells, Basal prostatic cells, Endometrial stromal cells, Urothelial cells, Pancreatic endocrine cells)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Prognostic marker in head and neck cancer (unfavorable), lung cancer (unfavorable) and pancreatic cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000107984-DKK1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000107984-DKK1/pathology/endometrial+cancer

OMIM: 605189

OMIM link2: https://www.omim.org/entry/605189

HGNC ID: HGNC:2891

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2891