Biomarker: YT521

Histology type: endometrial carcinoma

Country: Germany

Region: Freiburg

Followed up time :

Subgroup 1 name : YT521 IHC nuclear positive

Subgroup 1 number: 104

Subgroup 2 name: YT521 IHC nuclear naagtive

Subgroup 2 number: 26

Conclusion: We identified YT521 as a potential new independent prognostic factor for patients with EC: the lack of YT521 protein in tumor cells was highly predictive for a poor overall and disease-specific survival and independent from the histological subtypes.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : IHC nuclear nagetive expression

Statictics: cutoff<65;cutoff>65

Cohort age: 55;75

Funtion Uniprot: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity).

UniProt ID: Q96MU7

UniProt Link: https://www.uniprot.org/uniprotkb/Q96MU7/entry

Biological function from UniProt: #mRNA processing #mRNA splicing

Molecular function from UniProt:

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: YTH domain-containing protein 1

Gene name from HGNC: YTHDC1 (KIAA1966, YT521, YT521-B)

HPA class: Plasma proteins

AlphaFold DB: Q96MU7

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q96MU7

HPA link: https://www.proteinatlas.org/ENSG00000083896-YTHDC1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: General nuclear expression.

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Plasma membrane

Cancer prognostic summary HPA Prognostic marker in urothelial cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000083896-YTHDC1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000083896-YTHDC1/pathology/endometrial+cancer

HGNC ID: HGNC:30626

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30626