Basic information
Biomarker: HAI-1
Histology type: endometrial carcinoma
Cohort characteristics
Country: Japan
Region: Okayama
Followed up time :
Subgroup 1 name : weak epithelial staining
Subgroup 1 number: 20
Subgroup 2 name: moderate staining;high staining
Subgroup 2 number: 18;48
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 86 | EC | 56 | endometrial hyperplasia | 10 | uterine normal endometrium | 20 |
Sample information
Conclusion: These findings indicate that HAI-1 could be considered used as favorable prognosis markers for endometrial cancer.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : high expression (score 2)
Expression elevation: The level of HAI-1 staining in epithelial cells was classified into three groups by scoring the percentage of positive cells: strong (2); >50% of cells stained, moderate (1); 10–50% of cells stained, and weak (0); <10% of cells stained, Low epithelial expression, score 0–1; high epithelial expression, score 2
Disease information
Statictics: cutoff<60;cutoff>60
Cohort age: 32;24
Related information
Funtion Uniprot: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).
UniProt ID: O43278
UniProt Link: https://www.uniprot.org/uniprotkb/O43278/entry
Molecular function from UniProt:
Subcellular UniProt: #Secreted
Alternative name from UniProt:
Recommended name: Kunitz-type protease inhibitor 1
Gene name from HGNC: SPINT1 (HAI, MANSC2)
HPA class: Cancer-related genes Plasma proteins
AlphaFold DB: O43278
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O43278
HPA link: https://www.proteinatlas.org/ENSG00000166145-SPINT1
Tissue specificity RNA from HPA: Tissue enhanced (esophagus)
Tissue expression from HPA: Cytoplasmic expression in most tissues.
Single cell type specificity Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Proximal enterocytes, Distal enterocytes)
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA Located in Nucleoplasm, Plasma membrane, Cytosol
Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable) and breast cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000166145-SPINT1/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000166145-SPINT1/pathology/endometrial+cancer
OMIM: 605123
OMIM link2: https://www.omim.org/entry/605123
HGNC ID: HGNC:11246
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11246
