Biomarker: inhibin-α subunit

Histology type: endometrioid endometrial carcinoma

Country: Germany

Region: Munich

Study type: retrospective study

Followed up time :

Subgroup 1 name : Negative

Subgroup 1 number: 175

Subgroup 2 name: Positive

Subgroup 2 number: 56

Conclusion: Inhibin-α subunit expression in uterine endometrioid adenocarcinomas and endometrial cancer cell lines: a potential prognostic factor.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression(>0)

Expression elevation: The IRS score was calculated by multiplication of the optical staining intensity (graded as 0, no staining; 1, weak; 2, moderate; and 3, strong staining) and the percentage of the positive stained cells (0, no staining; 1, <10%; 2, 11-50%; 3, 51-80%; and 4, >81% of the cells).For the purposes of the statistical survival analysis, the median of the inhibin-· staining intensity for all tumor samples was used (median for inhibin-· = 0)

Statictics: cutoff<65;cutoff>65

Cohort age: 118;113

Subgroup 1 age: 83;92

Subgroup 2 age: 35;21

Funtion Uniprot: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

UniProt ID: P05111

UniProt Link: https://www.uniprot.org/uniprotkb/P05111/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.

Subcellular UniProt: #Secreted

Recommended name: Inhibin alpha chain

Gene name from HGNC: INHA

AlphaFold DB: P05111

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P05111

HPA link: https://www.proteinatlas.org/ENSG00000123999-INHA

Tissue specificity RNA from HPA: Group enriched (adrenal gland, ovary, testis)

Tissue expression from HPA: Distinct cytoplasmic expression in adrenal gland, Sertoli cells in testis and granulosa cells in ovary.

Single cell type specificity Cell type enhanced (Syncytiotrophoblasts, Granulosa cells, Theca cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Golgi apparatus, Vesicles (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000123999-INHA/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000123999-INHA/pathology/endometrial+cancer

OMIM: 147380

OMIM link2: https://www.omim.org/entry/147380

HGNC ID: HGNC:6065

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6065