Basic information
Biomarker: Nrf2
Histology type: endometrial serous carcinomas
Cohort characteristics
Country: USA
Region: Yale
Study type: retrospective study
Followed up time :
Subgroup 1 name : positive
Subgroup 1 number: 33
Subgroup 2 name: negative
Subgroup 2 number: 89
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 231 | EC | 122 | benign endometrium | 28 | precursor lesions | 81 |
Sample information
Conclusion: We conclude that Nrf2 overexpression is closely associated with endometrial neoplasms with serous differentiation. Alteration of Nrf2 expression may represent one of the early molecular events in ESC carcinogenesis and overexpression of Nrf2 may used as a diagnostic marker in surgical pathology.
Sample type : tissue
Sample method: Immunohistochemistry/Western blots
Expression pattern : overexpression
Disease information
Related information
UniProt Link:
Molecular function from UniProt:
Expression figure legend: Nrf2 immunostaining in endometrial precancerous lesions. | Nrf2 staining in endometrial serous carcinoma and its precursor lesions.
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016106/figure/fig01/?report=objectonly|https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016106/figure/fig02/?report=objectonly
