Biomarker: Stathmin

Histology type: endometrial carcinoma

Stage: high risk

Country: Norway

Region: Bergen

Study type: prospective multicenter study

Followed up time :

Subgroup 1 name : weak expression in curettage

Subgroup 1 number: 516

Subgroup 2 name: strong expression in curettage

Subgroup 2 number: 237

Conclusion: Stathmin immunohistochemical staining identifies endometrial carcinomas with lymph node metastases and poor survival. The value, as a predictive marker for response to PI3Kinase inhibition and as a tool to stratify patients for lymph node sampling in endometrial carcinomas, remains to be determined.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : overexpression(upper quartile, indices 6 and 9,redictive marker for response to PI3Kinase inhibition ,staining intensity and staining area, range 0–9)

Expression elevation: A semiquantitative grading system incorporating staining intensity (score 0–3) and area of tumor with positive staining (0, no staining;1, <10%; 2, 10%–50%; and 3, >50% of tumor cells) was applied. Staining index was calculated as the product of staining intensity and staining area, range 0–9.

Statictics: Mean ;Range

Cohort age: 66;28-94

Funtion Uniprot: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

UniProt ID: P16949

UniProt Link: https://www.uniprot.org/uniprotkb/P16949/entry

Biological function from UniProt: #Differentiation #Neurogenesis

Molecular function from UniProt:

Tissue specificity from UniProt: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Subcellular UniProt: #Cytoplasm #Cytoskeleton #Microtubule

Alternative name from UniProt:

Recommended name: Stathmin

Gene name from HGNC: STMN1 (C1orf215, FLJ32206, Lag, LAP18, OP18, PP17, PP19, PR22, SMN)

HPA class: Cancer-related genes

AlphaFold DB: P16949

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P16949

Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level)

HPA link: https://www.proteinatlas.org/ENSG00000117632-STMN1

Tissue specificity RNA from HPA: Tissue enhanced (brain, lymphoid tissue)

Tissue expression from HPA: Cytoplasmic expression in most tissues, including brain and lymphoid tissues

Single cell type specificity Cell type enhanced (Late spermatids)

Immune cell specificity: Immune cell enhanced (plasmacytoid DC)

Subcellular summary HPA Located in Cytosol (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in liver cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000117632-STMN1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000117632-STMN1/pathology/endometrial+cancer

OMIM: 151442

OMIM link2: https://www.omim.org/entry/151442

HGNC ID: HGNC:6510

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6510