Biomarker: CD151

Histology type: type II EC

Country: UK

Region: Bristol

Followed up time :

Conclusion: The CD151 is a novel marker in type 2 cancers that can guide therapeutic decisions. CD151 may have an important role in tumourigenesis in some histology types.

Sample type : tissue

Sample method: tissue microarray/immunohistochemistry

Expression pattern : expression(H-score ⩾150)

Expression elevation: CD151 were scored in a semi-quantitative manner incorporating both intensity of staining and distribution. Staining intensity (I) was graded as 0 (no staining), 1 (weak), 2 (moderate), or 3 (strong). The proportion (P) of cells (0–100%) with the observed staining intensity was recorded. A score (histologic or H-score) was determined as the product of the intensity and proportion using the formula (H=I × P).H-score=(1 × percentage of cells stained at intensity category 1)+(2 × percentage of cells stained at intensity category 2)+(3 × percentage of cells stained at intensity category 3). H-score between 0 and 300 was obtained where 300 was equal to 100% of tumour cells stained strongly. H-score ⩾150 was considered positive for the above markers.

Statictics: Mean ;Range

Cohort age: 68.2 (11.4, 37–89)

Funtion Uniprot: Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.

UniProt ID: P48509

UniProt Link: https://www.uniprot.org/uniprotkb/P48509/entry

Biological function from UniProt: #Host-virus interaction

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes

Subcellular UniProt: #Membrane

Alternative name from UniProt:

Recommended name: CD151 antigen

Gene name from HGNC: CD151 (PETA-3, RAPH, SFA-1, TSPAN24)

CD antigen name: CD151

HPA class: Blood group antigen proteins CD markers Disease related genes Human disease related genes Potential drug targets Transporters

AlphaFold DB: P48509

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P48509

Induction: By HTLV-1.

HPA link: CD151 protein expression summary - The Human Protein Atlas

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Membranous and cytoplasmic expression in all tissues except the CNS.

Single cell type specificity Cell type enhanced (Pancreatic endocrine cells, Ductal cells, Exocrine glandular cells)

Immune cell specificity: Low immune cell specificity

Cancer prognostic summary HPA Low immune cell specificity

Pathology link: https://www.proteinatlas.org/ENSG00000177697-CD151/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000177697-CD151/pathology/endometrial+cancer

Expression figure legend: Immunohistochemistry with antibodies to CD151, HER-2, integrins α6β1, α3β1 and E-cadherin.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101917/figure/fig1/

Survival figure legend: Kaplan–Meier survival curves demonstrating effect of CD151 expression on DSS and RFS in the entire cohort

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101917/figure/fig2/

Phenotype ID: 609057

Disease: Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD)

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 602243;179620;

OMIM link1: https://www.omim.org/entry/609057

OMIM link2: https://www.omim.org/entry/602243;https://www.omim.org/entry/179620;

Phenotype: RAPH BLOOD GROUP SYSTEM

HGNC ID: HGNC:1630

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1630