Biomarker: hGH

Histology type: endometrial carcinoma

Country: China

Region: Hefei

Followed up time :

Subgroup 1 name : mRNA

Subgroup 1 number: 34

Subgroup 2 name: Protein

Subgroup 2 number: 41

Conclusion: Tumor expression of hPRL expression, individually and combined, are associated with worse relapse-free survival and overall survival in patients with mammary or endometrial carcinoma.

Sample type : tissue

Sample method: situ hybridization and immunohistochemistry

Expression pattern : positive expression

Expression elevation: The sections were scored on the basis of the staining intensity and the percentage of cells with staining relative to the background: negative (-), having fewer than 10% of the epithelial cells stained positive; positive (+), having more than 10% of the cells stained positive.

Statictics: cutoff<60;cutoff>60

Cohort age: 57;13

Subgroup 1 age: 31;8

Subgroup 2 age: 32;8

Funtion Uniprot: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

UniProt ID: P01241

UniProt Link: https://www.uniprot.org/uniprotkb/P01241/entry#function

Molecular function from UniProt:

Subcellular UniProt: #Secreted

Alternative name from UniProt:

Miscellaneous: Circulating GH shows a great heterogeneity due to alternative splicing, differential post-translational modifications of monomeric forms, oligomerization, optional binding to 2 different GH-binding proteins, and potentially proteolytic processing.

Recommended name: Somatotropin

Gene name from HGNC: GH1 (GH, GH-N, GHN, hGH-N)

HPA class: Cancer-related genes Candidate cardiovascular disease genes Disease related genes Human disease related genes

AlphaFold DB: P01241

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P01241

HPA link: https://www.proteinatlas.org/ENSG00000259384-GH1

Tissue specificity RNA from HPA: Tissue enriched (pituitary gland)

Tissue expression from HPA: Cytoplasmic expression in cells in anterior pituitary gland and placenta.

Single cell type specificity Cell type enhanced (Adipocytes)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000259384-GH1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000259384-GH1/pathology/endometrial+cancer

Phenotype ID: 262400;612781;

Disease: Growth hormone deficiency, isolated, 1A (IGHD1A);Growth hormone deficiency, isolated, 1B (IGHD1B);Kowarski syndrome (KWKS);

Note1: The disease is caused by variants affecting the gene represented in this entry;The disease is caused by variants affecting the gene represented in this entry;The disease is caused by variants affecting the gene represented in this entry;

OMIM: 139250

OMIM link1: https://www.omim.org/entry/262400;https://www.omim.org/entry/612781;https://www.omim.org/entry/262650;

OMIM link2: https://www.omim.org/entry/139250

HGNC ID: HGNC:4261

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4261