Basic information
Biomarker: hPRL
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Hefei
Followed up time :
Subgroup 1 name : mRNA
Subgroup 1 number: 35
Subgroup 2 name: Protein
Subgroup 2 number: 41
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 140 | EC | 70 | hyperplasia | 32 | normal controls | 38 |
Sample information
Conclusion: Tumor expression of hGH in mammary or endometrial carcinoma is associated with a large and significant difference in survival outcome for patients with these tumors.
Sample type : tissue
Sample method: situ hybridization and immunohistochemistry
Expression pattern : positive expression
Expression elevation: The sections were scored on the basis of the staining intensity and the percentage of cells with staining relative to the background: negative (-), having fewer than 10% of the epithelial cells stained positive; positive (+), having more than 10% of the cells stained positive.
Disease information
Statictics: cutoff<60;cutoff>60
Cohort age: 57;13
Subgroup 1 age: 27;9
Subgroup 2 age: 31;10
Related information
Funtion Uniprot: Prolactin acts primarily on the mammary gland by promoting lactation.
UniProt ID: P01236
UniProt Link: https://www.uniprot.org/uniprotkb/P01236/entry
Biological function from UniProt: #Lactation
Molecular function from UniProt:
Subcellular UniProt: #Secreted
Alternative name from UniProt:
Recommended name: Prolactin
Gene name from HGNC: PRL
HPA class: Cancer-related genes Plasma proteins
AlphaFold DB: P01236
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P01236
HPA link: https://www.proteinatlas.org/ENSG00000172179-PRL
Tissue specificity RNA from HPA: Tissue enriched (pituitary gland)
Tissue expression from HPA: Selective expression in pituitary gland.
Single cell type specificity Group enriched (Late spermatids, Rod photoreceptor cells, Early spermatids)
Immune cell specificity: Not detected in immune cells
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000172179-PRL/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000172179-PRL/pathology/endometrial+cancer
OMIM: 176760
OMIM link2: https://www.omim.org/entry/176760
HGNC ID: HGNC:9445
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9445
