Biomarker: SNCG

Histology type: endometrial carcinoma

Country: USA

Region: NY

Study type: retrospective study

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 57

Subgroup 2 name: negative

Subgroup 2 number: 222

Conclusion: Overexpression of SNCG seemed to be a predictor biomarker for aggressive tumor behavior and adverse outcome in patients with endometrial cancer. Future exploration of SNCG as a potential therapeutic target for selected patients could be of interest.

Sample type : tissue

Sample method: immunohistochemisty

Expression pattern : Overexpression(negative and weak stains were grouped as group I (negative) and moderate and strong as group II (positive).)

Expression elevation: The stain intensity was diffuse and homogenous throughout the tumor. The extent of immunochemical reactivity was graded based on intensity as follows: 0 (negative), 1+ (weak), 2+ (moderate), 3+ (strong).For the sake of statistical analysis, negative and weak stains were grouped as group I (negative) and moderate and strong as group II (positive). 10 cases of normal endometrium were included to evaluate synuclein expression.

Statictics: Median;Range

Cohort age: 65; 29–97

Funtion Uniprot: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity)

UniProt ID: O76070

UniProt Link: https://www.uniprot.org/uniprotkb/O76070/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.

Subcellular UniProt: #Cytoplasm #Cytoskeleton

Alternative name from UniProt:

Recommended name: Gamma-synuclein

Gene name from HGNC: SNCG (BCSG1, persyn, SR)

AlphaFold DB: O76070

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O76070

HPA link: https://www.proteinatlas.org/ENSG00000173267-SNCG

Tissue specificity RNA from HPA: Tissue enhanced (adrenal gland, brain)

Tissue expression from HPA: Transporters

Single cell type specificity Cell type enhanced (Urothelial cells, Smooth muscle cells, Hepatic stellate cells, Adipocytes, Breast myoepithelial cells, Endothelial cells)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable) and stomach cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000173267-SNCG/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000173267-SNCG/pathology/endometrial+cancer

Expression figure legend: expression for synuclein

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047382/figure/F1/

OMIM: 602998

OMIM link2: https://www.omim.org/entry/602998

HGNC ID: HGNC:11141

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11141