Basic information
Biomarker: phosphatidylinositol 3'-kinase pathway alteration
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Beijing
Study type: retrospective study
Followed up time :
Subgroup 1 name : mutation
Subgroup 1 number: 29
Subgroup 2 name: wide
Subgroup 2 number: 53
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 196 | EC immunohistochemistry group | 102 | PIK3CA mutation status sequence group | 94 |
Sample information
Conclusion: Our findings suggest that phosphatidylinositol 3'-kinase pathway alteration might have a favorable prognostic impact on endometrial cancers in Chinese women. Furthermore, the function of the phosphatidylinositol 3'-kinase pathway might be affected by estrogen receptor status.
Sample type : tissue
Sample method: immunohistochemistry/sequencing analyz
Expression pattern : pathway alteration
Expression elevation: The p-AKT staining was evaluated using the H-score, which was calculated by multiplying the PP (0-100%) by the corresponding SI (1 =weak, 2 = moderate, and 3 = strong),Cases of p-AKT H-scores more than 50 were considered positive.
Disease information
Statictics: Median;Range
Cohort age: 55;32-79
Related information
UniProt Link:
Molecular function from UniProt:
