Basic information
Biomarker: TIMP-2
Histology type: endometrial carcinoma
Cohort characteristics
Country: Finland
Region: Oulu
Followed up time :
Subgroup 1 name : Negative
Subgroup 1 number: 34
Subgroup 2 name: Positive
Subgroup 2 number: 207
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 241 | primary endometrial carcinoma | 241 |
Sample information
Conclusion: We suggest that TIMP-2 may have a more important role in endometrial carcinoma progression than TIMP-1 and might serve as a potential marker for favorable prognosis in this type of cancer.
Sample type : tissue
Sample method: immunohistochemisty
Expression pattern : expression
Expression elevation: The staining was considered intensive when more than 50% (+++) of the neoplastic cells showed a positive reaction for TIMP-2.)
Disease information
Related information
Funtion Uniprot: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
UniProt ID: P16035
UniProt Link: https://www.uniprot.org/uniprotkb/P16035/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Down-regulated by TGFB1
Subcellular UniProt: #Secreted
Alternative name from UniProt:
Recommended name: Metalloproteinase inhibitor 2
Gene name from HGNC: TIMP2 (CSC-21K)
HPA class: Cancer-related genes Candidate cardiovascular disease genes Plasma proteins
AlphaFold DB: P16035
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P16035
HPA link: https://www.proteinatlas.org/ENSG00000035862-TIMP2
Tissue specificity RNA from HPA: Tissue enhanced (ovary)
Tissue expression from HPA: Extracellular deposits and cytoplasmic expression in all tissues.
Single cell type specificity Cell type enhanced (Peritubular cells, Late spermatids, Fibroblasts, Leydig cells)
Immune cell specificity: Immune cell enhanced (neutrophil)
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000035862-TIMP2/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000035862-TIMP2/pathology/endometrial+cancer
OMIM: 188825
OMIM link2: https://www.omim.org/entry/188825
HGNC ID: HGNC:11821
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11821
